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Single-crystal cubic silicon carbide
12-10-2020, 09:23 AM,
Post: #1
Single-crystal cubic silicon carbide
Single-crystal cubic silicon carbide: an in vivo biocompatible semiconductor for brain machine interface devices
Single crystal silicon carbide (SiC)hsl abrasive is a wide band-gap semiconductor which has shown both bio- and hemo-compatibility [1-5]. Although single crystalline SiC has appealing bio-sensing potential, the material has not been extensively characterized. Cubic silicon carbide (3C-SiC) has superior in vitro biocompatibility compared to its hexagonal counterparts [3, 5]. Brain machine interface (BMI) systems using implantable neuronal prosthetics offer the possibility of bi-directional signaling, which allow sensory feedback and closed loop control. Existing implantable neural interfaces have limited long-term reliability, and 3C-SiC may be a material that may improve that reliability. In the present study, we investigated in vivo 3C-SiC biocompatibility in the CNS of C56BL/6 mice. 3C-SiC was compared against the known immunoreactive response of silicon (Si) at 5, 10, and 35 days. The material was examined to detect CD45, a protein tyrosine phosphatase (PTP) expressed by activated microglia and macrophages.  wholesale silicon carbideThe 3C-SiC surface revealed limited immunoresponse and significantly reduced microglia compared to Si substrate.
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